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As a natural flavonoid in fruits and vegetables, C3G offers a cost-effective, orally available option to complement GLP-1 receptor agonists, with particular benefits for resource-limited settings

The in vivo HITI-mediated knock-in efficiency at the Alb locus in this study is comparable to that of other knock-in methods, such as HDR (~2%) and NHEJ (~2%) 33,34

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While both medications reduce appetite through different mechanismsphentermine via sympathomimetic stimulation and semaglutide through GLP-1 receptor activationthe combined effect on appetite suppression, cardiovascular parameters, and metabolic function has not been systematically studied in large populations