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Nevertheless, the pooled analysis of 16 trials suggested improvements in the summary measure of patients' global functioning (assessed with the Clinical Global Impressions [CGI-I] scale) after 12 and 24 weeks of (but not after 52 weeks) of ALCAR treatment (1-3 g/day) and in cognitive performance (assessed with the Mini-Mental State Examination [MMSE] scale) after 24 weeks (but not at 12 or 52 weeks) (104)

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It also appears to support angiogenesis and counteract the negative effects of corticosteroids on healing. However, despite over two decades of preclinical research, there is a paucity of clinical trials evaluating its use for musculoskeletal injuries in humans, and it remains unapproved for medical use by regulatory bodies. Collagen peptides do have human clinical data

COX2 is an enzyme that plays an important role in the synthesis of prostaglandins involved in inflammatory responses (225)