Semaglutide is delivered through a tiny injection that is virtually pain free
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Our complete semaglutide vs tirzepatide comparison guide covers this in detail, but here are the key differences in weight loss outcomes: Average Weight Loss Comparison Semaglutide (STEP-1 trial, 68 weeks): Average weight loss: 14.9% 69.1% lost 10% or more 50.5% lost 15% or more Tirzepatide (SURMOUNT-1 trial, 72 weeks at 15 mg dose): Average weight loss: 22.5% 89% lost 10% or more 78% lost 15% or more Tirzepatide shows higher average weight loss in clinical trials, though both medications demonstrate significant effectiveness
Postmenopausal bleeding (any vaginal bleeding occurring more than 12 months after the last menstrual period) requires prompt GP assessment and referral via the urgent suspected cancer pathway (two-week wait) in line with NICE guidance (NG12)
