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In the kidneys, GPER expression is closely related to the reabsorption and excretion of calcium, and studies have shown that GPER activation can promote the reabsorption of calcium in renal tubules, thus maintaining blood calcium levels [134]

The authors noted that results from more recent studies were less positive than those from earlier studies, and concluded that routine clinical use of ALCAR to treat dementia signs and symptoms was not justified [15]