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Moreover, the cytotoxicity studies provide compelling evidence of the biocompatibility of the nanocarrier without ENZ and its potent anticancer activity when loaded with ENZ

Recent studies also indicate that excess intracellular iron can modulate necroptosis and pyroptosis, suggesting that disrupted iron homeostasis is not exclusive to ferroptosis

However, side effects like nausea, dizziness, or gastrointestinal discomfort may also become more likely as the dose increases

A quantitative summary of the most significantly enriched metabolic routes, along with matched metabolite counts and corresponding false discovery rates (FDR) (Fig