The potential gastrointestinal side effects of these drugs can also further limit food intake, Stanford said, which can "lead patients to avoid certain foods, sometimes worsening nutritional gaps." Therefore, while GLP-1 medication is known for being highly effective, experts warn patients need to ensure they are paying close attention to their dietary needs and wider health while using the drugs
In humans, GLP-1Rs are found in a variety of tissues, including pancreatic islets, the lungs, the kidneys, the gastrointestinal tract, the central nervous system, the vagus nerve, endothelial cells and smooth muscle cells, as well as in atrial and ventricular cardiomyocytes
At the end of the trial, compared to the group taking sulfonylureas, participants who consistently took GLP-1 medications for the entire three-year period of the study had the most pronounced reduction in risk 18%, or roughly 4 fewer major cardiovascular events per 100 people over three years
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