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It is well documented that concomitant use of the CYP2E1 inducer isoniazid increases the risk of hepatotoxicity, though whether 2E1 induction is related to the hepatotoxicity in this case is unclear.[40][41] Concomitant use of other drugs that induce CYP enzymes such as antiepileptics (including carbamazepine, phenytoin, and barbiturates) have also been reported as risk factors

NOS1 catalyzes the production of nitric oxide (NO), a crucial neurotransmitter involved in brain development, synaptic plasticity, learning, and memory processes [78, 79]

However, numerous challenges remain, such as the dynamic nature and heterogeneity of cell death modes, optimizing multi-target combination therapies, and achieving precision medicine

Klotz MG, Loewen PC