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Journal of Investigative Dermatology 113, 10061010

168 The 2020 KDOQI guidelines for the management of kidney diseases recommends that people with stage 35 CKD who are not receiving dialysis eat a low-protein diet (0.550.60 grams per kilogram of body weight per day [g/kg/day]) or a very-low-protein diet (0.280.43 g/kg/day) supplemented with 715 grams of keto-analogues of essential amino acids

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Additionally, it has a significant positive impact on the Social Responsiveness Scale (SRS) and Clinical Global Impressions - Efficacy (CGI-E) scores, but has no significant effect on sensory symptoms (161)