Clinical history, medication and phenotypic information were acquired as described 26,31,41,63 with standardized procedures across centers
In addition to the primary outcome of SELECT, nominally statistically significant risk reductions were also seen in secondary efficacy endpoints, including heart failure composite endpoint, all-cause mortality, coronary revascularizations, sustained weight loss for 104 weeks, a 5-point nephropathy composite endpoint, and patients developing biochemical diabetes (at least one post-randomization glycated hemoglobin [HbA 1c ] 6.5%) [21]
Semaglutide (Ozempic) is also used in the management of type 2 diabetes in line with NICE guideline NG28
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