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Dietary supplements present a documented risk for anti-doping violations because they remain outside WADA regulations and are frequently contaminated

This first-pass mechanism of periportal toxicity for selected compounds, including hepatotoxicants that primarily affect centrilobular hepatocytes, could result from deficient cytoprotective capacity secondary to depletion of phase II conjugating enzymes in addition to being a consequence of a higher exposure gradient to these upstream hepatocytes

The compound's mechanism -- uncoupling mitochondrial respiration to generate heat instead of ATP -- carries inherent risks

Interleukin-1 inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)