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The -cyano amide-based Michael acceptors have also been elegantly used by the Taunton group as warheads in small-molecule inhibitors to react with active site cysteines while being minimally affected by the high concentration of intracellular GSH due to the fast reaction kinetics and the mM of K d (refs 31, 32)

Mechanisms and insights into drug resistance in cancer

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If it makes a difference to any patient, its a win, said Mark Cuban, a billionaire investor on his own mission to bring down drug prices