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Plunger becoming stiff or sticky After several days in storage, you might find that the syringe plunger resists smooth movement

Side effects/Contraindications The most common side effects include nausea and constipation.* If you or any family members have been diagnosed with Multiple Endocrine Neoplasia Syndrome Type 2 or Medullary thyroid cancer you should not take Semaglutide

This is more of a long-term concern than an immediate cause of early fatigue, but its worth considering if tiredness persists or worsens after several months of treatment

Both semaglutide and tirzepatide injections need to be stored in the refrigerator, but you shouldnt put them in the freezer, as it could damage your medication