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Finally, any molecule absorbed through the gut wall must pass through the liver in what's called the 'first-pass effect,' where hepatic enzymes can further metabolize and deactivate it before it ever reaches the rest of the body

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IRF1 drives the expression of the transferrin receptor, promotes intracellular Fe2+ accumulation, disrupts iron homeostasis, and induces ferroptosis in cancer cells, while blocking Gln enhances this effect (92)

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What should I watch for that might indicate a hormonal shift

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Additionally, looking at a complete blood count to check for big red blood cells (macrocytosis), is another way your doctor may pick up if there is a potential B12 or other B vitamin deficiency

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