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These channels are often made by several subunits, including subunits (1-10), (1- 4), , , and subunits, which are heteromeric receptors [20, 21]

Rodrigues, M

### The STEP 5 Study: Long-Term Adherence The STEP 5 two-year extension study (*Nature Medicine*, 2022) showed: - Patients who maintained consistent dosing for 2 years sustained an average weight loss of 15.2% - Adherence was the strongest predictor of long-term success - Patients who missed occasional doses (but did not discontinue) still achieved meaningful results - The difference between "perfect" adherence and "good" adherence (missing 12 doses per quarter) was relatively small **Key takeaway**: Don't panic about occasional missed doses