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Other reported effects included: Transient fatigue Reduced appetite (therapeutically desirable in the context of weight loss) Mild injection-site reactions Altered skin sensations or cutaneous hyperesthesia (reported in ~7% of participants, mild and non-serious) Serious adverse events were rare and occurred at similar rates in the retatrutide and placebo groups (approximately 4%)

Altogether, these data suggest that by eliminating auto-reactive humoral response against ACTH and by compensating for the lack of ACTH, the immune response against infection is improved (42)

Lingvay, B

Eur J Rheumatol Inflamm 4(2):173182 Ighodaro OM, Akinloye OA (2018) First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid