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Intermuscular adipose tissue-derived inflammatory adipokines, exacerbated by aging, obesity, and sedentary behavior, promote both fat accumulation and chronic inflammation within skeletal muscle, driving adipogenic differentiation at the expense of myogenesis and thereby contributing to reduced muscle quality and increased metabolic risk [81]

For someone with an A1C of 8.5%, tirzepatide 15mg could potentially bring that below 6.5%, which is below the diagnostic threshold for diabetes

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De-Ritis ratio is associated with mortality after cardiac arrest