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Ramracheya R, Ward C, Shigeto M et al (2010) Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets

Aside from generating both NADPH and ribose 5-phosphate, the PPP can operate four different modes where NADPH and/or ribose 5-phosphate is produced, depending on the cellular metabolic demands (Fig