Moreover, the normal NP is an avascular and aneural tissue, where NP cells are far at least 8 mm from the nearest blood supply [22], which makes nutrients and waste exchange based solely on diffusion and self-healing extremely difficult to achieve [23]
The research record is based on animal models and mechanistic reasoning
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For this reason, we prefer to define this disease as Recurrent Intrahepatic Cholestasis (RIC) rather than a form of benign cholestasis (BRIC) in this review, given the possible risk of progression over the years