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Are Wegovy (semaglutide) and Mounjaro (tirzepatide) taken the same way
Consistent with this, KEGG pathway analysis revealed downregulation of -oxidation in KO mice, accompanied by upregulation of glycolysis and mitochondrial oxidative phosphorylation, reflecting a systemic shift in fuel preference toward carbohydrates driven by carnitine depletion and impaired fatty acid oxidation
Together, these findings indicate that the p53 signalling pathway is induced in an adipocyte-autonomous manner in response to nutrient reduction, and might control the apoptotic fate and inflammatory response of adipocytes under metabolically challenging conditions
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