Conclusion: This study suggests those with TIA, compared to healthy controls, have greater p-tau and lower beta-amyloid suggesting an early AD type biomarker profile which may in part explain the increased risk of dementia post-TIA
All data presented as mean SEM
In brief, after 8 h of preoperative water and food fasting, adult male SpragueDawley (SD) rats weighing 275 25 g (purchased from Spearfish, China) were sedated in an induction chamber with isoflurane (oxygen flow rate of 3 L/min, 5 mL/kg) and then injected with an intramuscular injection of 1% pentobarbital (Wampanoag, P11011, Germany) at a concentration of 0.5 mL/100 g, and then observed for 35 min until the rats entered deep anesthesia
Tajbakhsh S, Aliakbari K, Hussey DJ, Lower KM, Donato AJ, Sokoya EM