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High-protein diets can increase renal metabolic burden and promote the generation of harmful metabolites derived from intestinal protein fermentation, while Western dietary patterns characterized by high fat and sugar intake are closely associated with insulin resistance, chronic low-grade inflammation, and gut microbiota dysbiosis ( The human intestinal tract is colonized by trillions of microorganisms that participate in various physiological processes including food digestion, synthesis of essential vitamins and amino acids, pathogen antagonism, and toxin clearance ( A close triangular interaction exists among diet, gut microbiota, and host metabolism