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Further study needs to be performed to explore the downstream signals of MAPK pathway, especially changes in the level of transcription factors

Severity grading After a complete physical examination and full laboratory investigations, grading of the patient was done on admission and after 24 h

Injection to a nerve may cause some amount of pain initially but at tolerable levels

Under high glucose conditions Ex-4 was able to reverse glucose-induced suppression of proliferation in human Periodontal ligament stem cells (PDLSC) [17] and reduced cellular senescence in hMSC as confirmed by EdU staining, flow cytometry and cell cycle analysis [18]