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This is consistent with the methyl folate trap hypothesis (54), which predicts that, in vitamin B-12 deficiency, the inhibition of DNA synthesis and cell proliferation is removed upon administration of high doses of folic acid because of increased availability of nonmethylated folate

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We may recommend a weekly or biweekly injection to reverse deficiencies, commonly for B-12 shots, or an injection in conjunction with certain treatments for best results

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