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Among 18 studies assessing adults without mental illness, eight found GLP-1 use improved mental state and 10 studies found improvements in quality of life with GLP-1s

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Research suggests that inconsistent dosing can reduce the overall effectiveness of treatment, as the receptor stimulation that suppresses appetite and regulates glucose becomes irregular

As both the liver and skeletal muscle store most of the glycogen in humans, current research supporting increased glucose uptake and glycogen synthesis within these tissues provides plausibility in explaining the phenomenon where individuals prescribed GLP-1 agonists can consume greater amounts of carbohydrates while still losing weight