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The dependence of tyrosine hydroxylase on BH 4 necessitates the coupling to the action of dihydropteridine reductase (encoded by the QDPR gene: quinoid dihydropteridine reductase) as is the situation for tryptophan hydroxylase (see below) and phenylalanine hydroxylase
Apart from other genes, glutathione S-transferase Mu class gene (GSTM1) from the human genome has been edited using CRISPR-Cas9 system (Sanjana et al., 2014)
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