tirzepatide mg and Semaglutide key differences, weight loss results (2026) Tirzepatide dosage chart in units:

The choice between the pill and injection depends on your personal goals, lifestyle, and tolerance for potential side effects

[1] [2] It is administered once weekly via subcutaneous injection and should be used alongside diet, physical activity and behavioural support

Weeks 1-4: 0.25 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Weeks 5-8: 0.5 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Weeks 9-12: 1.0 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Weeks 13-16: 1.7 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Week 17 and beyond: 2.4 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Some providers modify this schedule based on individual tolerance

Before each injection, youll need to first listen for 2 additional clicks that let you know that the pen has been activated, or primed