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In microglia, GLP-1R activation via PI3K/Akt signaling also reduces neuroinflammation by modulating NF-B activity, decreases the production of pro-inflammatory cytokines, increases anti-inflammatory markers such as IL-10, IL-4, Arginase, and CD206, and the transformation of microglia into an anti-inflammatory state

The risk appears higher compared with SGLT2i diabetes medications, though NAION remains uncommon

The Advertising Standards Authority (ASA) and the Committee of Advertising Practice (CAP) Code set clear restrictions on weight control and weight loss claims for food supplements in UK advertising

While urine that smells like ammonia is usually harmless, there are instances where medical treatment is required to prevent more serious complications