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In the SIMGI model (an in vitro simulator of human digestion), a single dose of 0.166 g of PLAa widely used biodegradable plastic was followed by 72-h colonic fermentation

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In line with our results from our mouse models, these data from clinical tumor samples further support the importance of fine-tuning the redox state in concert with inactivation of A2AR signaling in intratumoral CD8 + T cells for favoring the antitumor immune response