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The ones used to secure FDA approval

Elevated polyamine levels are necessary for neoplastic transformation and tumor progression (Casero et al., Arginine and arginine-dependent polyamine production are important not only for biomass synthesis, which supports tumor aggressiveness, but also as regulators in immunometabolism (Mondanelli et al., 2017), which represents an important target for effective cancer immunotherapy

Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway