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2B show that the presence of 2 M PSC-833, a specific inhibitor of P-gp ATPase [33], reverses the collateral sensitivity of CHO R C5 and MDA-Doxo 400 cells to tamoxifen, with shift in IC 50 values from 0.900 0.090 and 3.582 0.048 M to 2.998 0.071 and 4.336 0.895 M with PSC-833 for CHO R C5 and MDA-Doxo 400 , respectively

In humans, meta-analyses of intervention studies using carnitine have documented reductions in body weight and fat mass in overweight and obese adults [4] , as well as markers of systemic inflammation , including C-reactive protein (CRP), tumor necrosis factor alpha (TNF-), and interleukin-6 (IL-6) [5,6]