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Clinical Information Pernicious anemia is a complex condition stemming from a vitamin B12 deficiency, essential for making red blood cells and maintaining a healthy nervous system

The 1858 C/T SNP of the PTPN22 gene is a risk factor for HT because it causes an arginine-tryptophan substitution at codon 620 (R620W), because decreased T cell signaling may results in poorer thymic elimination of autoreactive T cells, or an increased function of PTPN22 may lead to a decrease in regulatory T cells (Tregs) responsible for preventing autoimmunity

Light exposure introduces a separate degradation pathway: photodegradation