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In addition, GPER can influence the progression of NAFLD by regulating hepatocyte apoptosis and autophagy, helping to alleviate the cell damage caused by liver inflammation [77, 171]

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MAPKs, including extracellular signal-regulated kinases (ERK), c-Jun N-terminal kinases (JNK), and p38 MAPKs, regulate various cellular activities such as growth, differentiation, and apoptosis

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