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It is difficult to evaluate the extent to which glucose-independent mechanisms are involved in renoprotection by GLP-1RAs

MET expression can be detected at a sub-cellular level in the growth-cone of P0 mice developing cortical tissue as well as in cultured hippocampal neurons, suggesting a functional role mediated by MET in neuronal growth (Peng et al., 2016)

Further research, including controlled studies with proper single-compound comparison groups, is needed to validate any combined effect

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