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Heat changes tendon biology, training load tolerance shifts, and overuse injuries to the Achilles, plantar fascia, and patellar tendon are well-documented [British Journal of Sports Medicine, 2019]

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Retatrutide's phase 2 obesity data (around 24% at the top dose) edged tirzepatide's SURMOUNT-1 result (about 21%), but they come from different trials, not a head-to-head, and retatrutide is not approved