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There is evidence to suggest that mutations in the MAGEL2 gene may contribute to the characteristic weight gain seen in individuals with PWS

Design of in vivo Experiments The animals were separated into 4 groups according to the treatment schedule, as follows: saline (saline 0.9% + cecal ligation and puncture CLP/ n = 18 animals), Ceftriaxone (Cef 20 mg/kg + CLP/ n = 6 animals), aqueous extract of Ab (Ab 135 mg/kg + CLP, n = 18 animals) and sham (surgery control, n = 18 animals)