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The most common Zepbound side effects tend to be nausea, constipation, diarrhea, indigestion, and vomiting, but you may also experience other mild and, in rare cases, more severe side effects

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For example, GLP-1R-expressing vagal afferents have been shown to form intraganglionic laminar endings (IGLEs) mainly in the wall of the stomach/upper duodenum in mice [31, 32], such that they are selectively activated by gastric/duodenal stretch and CCK, but unexpectedly, not by exendin-4 [32]