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Colvin, which looked at birth records in Western Australia between 2002 and 2005, did not detect any adverse outcomes from the use of ondansetron in pregnancy but could not conclude that ondansetron is safe to use in pregnancy. While the study was too small to assess risks of individual birth defects (only 251 births associated with the drug out of almost 97,000 births total), the researchers found a six-fold increase in the risk for kidney malformations associated with ondansetron