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Fifteen broadly neutralizing mAbs were isolated from macaques that could neutralize a panel of pseudoviruses carrying spike proteins of SARS-CoV-2 variants, including Omicron BA.1 and BA.4/5, and SARS-CoV-1 [147]

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Third, the discovery that MOTS-c also plays roles in immune regulation, particularly in suppressing innate immune overactivation, has opened research directions in inflammation-driven aging, autoimmunity, and potentially long-term sequelae of infections