semaglutide cardiovascular outcomes news today 2025 #VisualAbstract: and in Obesity without Diabetes SELECT Trial

4 Discussion The improvement of semaglutide on obese individuals is significant, and the main mechanism of this type of GLP-1RA is to stimulate GLP-1R, triggering activation of several metabolic pathways involved in insulin secretion, lipid metabolism, energy expenditure, cell survival, anti-apoptotic signaling, and oxidative stress prevention in tissues such as the pancreas, central nervous system, heart, muscles, kidneys, and intestines (Rowlands et al., 2018)

Stable blood sugar reduces cravings, especially for sugary or high-calorie foods, which can lead to overeating

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