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1 Introduction Hypercholesterolemia or dyslipidemia occurs when low-density lipoprotein (LDL) rises and accumulates fat in the arteries (atherosclerosis) and cardiovascular diseases, increasing the risk of heart attacks and contributing to more deaths ( In addition, hyperlipidemia induces oxidative stress through the buildup and oxidation of low-density lipoproteins (LDL) cholesterol in artery walls, which leads to inflammation and ultimately artery narrowing that, in turn, raises the risk of heart attacks, strokes, and cardiovascular diseases ( Chemical-based medicines may cause adverse reactions, such as liver problems, nausea, drowsiness, diarrhea, or allergic reactions, known as an adverse drug reaction (ADR) ( The safflower ( Carthamus tinctorius L