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Specifically, inhibiting or depleting spinal microglia abolished the anti-allodynic effects of morroniside, while neutralizing IL-10 or -endorphin with targeted antibodies, or blocking the -opioid receptor, fully reversed morroniside-induced mechanical anti-allodynia [74]

The growth is propelled by its strong clinical performance and extended half-life properties

Notably, older adults with obesity and preserved baseline muscle mass represent a particularly understudied phenotype, and dedicated studies are needed to determine whether this subgroup may differentially benefit from the muscle quality improvements associated with GLP-1 RA therapy

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