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Pregnant or breastfeeding women should avoid both compounds

Adversely, iGluR antagonists CNQX, DNQX, and DL-2-amino-5-phosphonopentanoic acid (AP-5) show an inhibitory effect on Ca 2+ signaling and pollen tube growth (Michard et al., 2011)

Dominy, J

ALS is mostly diagnosed based on clinical signs, using the revised El Escorial criteria, which require signs of both upper motor neuron (e.g., spasticity, brisk reflexes) and lower motor neuron damage (e.g., muscle wasting, twitching) in multiple body regions (Kwan and Vullaganti, 2022)