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Per unit mass, the myocardium consumes most of the KB ( In the hypertrophied and failing heart, decreased myocardial capacity for fatty acid oxidation occurs, leading to enhanced cardiac glucose utilization through anaerobic glycolysis, pyruvate accumulation and lactate production

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Reductions of E3 ligase function may cause APP accumulation and A generation, whereas, overexpression of these E3 ligases may result in decreased level of A in in vitro models

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