Where it works: Liver: Increases hepatic glucose production and fat oxidation (when carbs are low) Adipose tissue: Stimulates lipolysis (breakdown of stored fat into free fatty acids) Brown adipose tissue: Activates thermogenesis (heat production from burning fat) Muscle: May increase fat oxidation during exercise Weight loss contribution: The glucagon component appears to add an additional 2-3% weight loss beyond the GLP-1/GIP combination (24% vs 22% for tirzepatide)
Silk AW, Kaufman HL, Curti B, Mehnert JM, Margolin K, McDermott D, et al
The Precision Peptide Genetic Test maps 14 pathways, 49 peptides, 150+ genetic insights, MTHFR and MTRR among them, so the terrain is visible before a protocol enters it
Remember that you may need to adjust medication during hormonal transitions like pregnancy, postpartum, and menopause, during times of high stress, or when you change your diet and lifestyle