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Abnormalities of Homocysteine Metabolism Dysfunctions related to congenital defects in enzymes involved in homocysteine metabolism, to deficiencies in the supply, absorption, or metabolism of folates, vitamins B 12 and B 6 , and to dietary methionine excess all contribute to increasing plasma homocysteine levels (Table 1)

Some studies have shown that, if people with Down syndrome take the inactive oral forms of vitamin B12 and folate, their bodies may have difficulty converting from the inactive to the active form and the inactive form may not be as effective

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