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Thioredoxin-1 (Trx-1) is a multifunctional molecule that has anti-inflammatory properties in human tissues and plays significant neuroprotective roles in AD (Jia et al., 2024)

However, with no prospective randomized controlled trials (RCTs) for either therapies or approaches (NBS programs) and very low numbers of affected individuals, assigning letter grades of literature evidence quality is difficult