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Gallbladder Disease: A meta-analysis of GLP-1 research identified an elevated risk of gallbladder and biliary disorders among users of these medications, particularly at higher doses and with prolonged use

So to understand what is likely in those vials, you have to look at the one GLP-1 the scientists have tested, and extrapolate down from the easy case to the hard one

This is the first Phase 3 GLP-1-class readout that specifically demonstrates symptomatic benefit in knee osteoarthritis beyond what would be expected from weight loss alone, and it opens the possibility, still to be confirmed in dedicated trials, that GLP-1 receptor signaling has direct anti-inflammatory or disease-modifying effects on joint tissue

R., Bienkowska-Haba M., Guion L