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Nitric oxide in skeletal muscle: role on mitochondrial biogenesis and function

This synergy operates through multiple mechanisms [7] : The REDEFINE 1 trial demonstrated that CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg) produced 15.6% weight loss compared to 10.8% with cagrilintide alone and historical data of ~15% with semaglutide alone, suggesting true synergy [7]