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3.2.2 Disease Resistance and Aging IF promotes autophagy, which facilitates the removal of damaged organelles and misfolded proteins, thereby reducing oxidative stress and inflammation, both of which are crucial in aging and neurodegenerative diseases [24]

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3.3.2 Iron overload under high glucose promotes ROS generation and triggers ferroptosis HG disrupts iron homeostasis: upregulated TFR1 (iron uptake) and downregulated FTH1 (iron storage) lead to LIP expansion (129, 130)

Patients are advised to report any unusual or persistent stomach discomfort to their healthcare provider, ensuring timely intervention and management of any serious underlying conditions