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Tirzepatide specifically, as a dual GLP-1/GIP agonist, showed more pronounced reductions in LDL, triglycerides, and total cholesterol compared to placebo and SGLT2 inhibitors in a different paper

Cardiovascular Responses to Chemical Stimulation of the Hypothalamic Arcuate Nucleus in the Rat: Role of the Hypothalamic Paraventricular Nucleus

In clinical studies treatment with liraglutide was associated with an increase in HR (mean difference 7 bpm) and more serious cardiac adverse events (3% vs 10% for placebo and liraglutide, respectively) in chronic heart failure patients with and without type 2 diabetes (135)

Heres how to ride it out: Step 1: Breathe Deeply